A 37-year-old man is dead and five others were hurt in a head-on crash just outside Miramichi.
It happened at about 5 p.m. on Saturday near Derby Junction.
Police say the man died at the scene and was the only person in one of the vehicles.
The five people riding in the other vehicle are dealing with serious injuries and were taken to the hospital for treatment.
The crash is believed to have occurred when one of the vehicles crossed over the center line into oncoming traffic.
The investigation is continuing.